Symptoms

Neither adding view restriction or edit restriction will update the screen with the appropriate restriction.

Diagnosis

Firebug or Chrome Developer tools shows 404 when clicking on the "me" element. Changing to a different theme corrects the problem.

Cause

You may have an invalid page layout specified.

Resolution

1. Go to Admin >> Layouts >> Page Layouts
2. If there's a non default layout, edit it, then save it in a file for backup.
3. Restore to defaults.